Cancer patients are particularly vulnerable to the impact of COVID-19 pandemic as a result of greater health-related risks and concerns for delayed or suboptimal care. However, for racial and ethnic minority women diagnosed with breast cancer, current institutional measures implemented to regulate access to healthcare settings and modifications of treatment regimens may exacerbate the existing disproportionate burden of the disease. This study will further understanding of the impact that the COVID-19 pandemic has on the cancer care received by non-Hispanic Black and Hispanic women by assessing differential rates of cancer care disruption and health-related quality of life and by examining how proximal, intermediate, and distal determinants of disparities differentially contribute to these outcomes. This type of research is needed to inform future interventions able to sustain effective models of cancer care delivery in a post-acute COVID-19 environment.